Lower resp tract infections including bronchitis & pneumonia; skin & soft tissue infections; acute otitis media & URTI including sinusitis & pharyngitis/tonsillitis. Eradication of streptococci from oropharynx. Uncomplicated genital infections due to Chlamydia trachomatis & non-multiresistant Neisseria gonorrhoea. Chancroid due to Haemophilus ducreyi. Powd for oral susp: Alone or in combination w/ rifabutin for prophylaxis against Mycobacterium avium-intracellulare complex (MAC) infection.
Dosage/Direction for Use
Adult STD1,000 mg as single oral dose. Other indications 1,500 mg given as 500 mg daily for 3 days or given for 5 days w/ 500 mg on day 1 then 250 mg daily on days 2-5. Childn >45 kg Adult dose, 36-45 kg 400 mg once daily on days 1-3 or 400 mg on day 1 then 200 mg once daily on days 2-5,26-35 kg300 mg once daily on days 1-3 or 300 mg on day 1 then 150 mg once daily on days 2-5, 15-25 kg 200 mg once daily on days 1-3 or 200 mg on day 1 then 100 mg once daily on days 2-5, <15 kg 10 mg once daily on days 1-3 or 10 mg on day 1 then 5 mg/kg once daily on days 2-5. Acute otitis media 30 mg/kg as single dose. Ped Streptococcal pharyngitis 10 or 20 mg/kg as single dose for 3 days. Max dose: 500 mg daily. Powd for oral susp Prophylaxis against MAC infections 1,200 mg once wkly.
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