Sacubitril and Valsartan
In combination w/ other heart failure therapies in adult patients w/ chronic heart failure to reduce risk of CV death & hospitalization due to heart failure, administered in place of ACE inhibitors or ARB. Benefits are most clear in patients w/ LVEF below normal.
Dosage/Direction for Use
Adult Initially 100 mg bd, doubled up to 200 mg bd every 2-4 wk as tolerated. Patient not currently taking ACE inhibitor or ARB Initially 50 mg bd, slowly titrate dose doubled every 3-4 wk. Patient w/ systolic BP (SBP) ≥100-110 mmHg, moderate (eGFR 30-60 mL/min/1.73 m2) to severe renal (eGFR <30 mL/min/1.73 m2) & moderate hepatic impairment (Child-Pugh B) Initially 50 mg bd.
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