Simvor 10mg Tablet (10’s)

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Reduction in risk of CHD deaths, non-fatal MI & stroke & the need for coronary & non-coronary revascularization procedures. Adjunct to diet to reduce elevated total-C, LDL-C, Apo B & TG & increase HDL-C in patients w/ primary & heterozygous familial hypercholesterolemia or combined (mixed) hyperlipidemia when response to diet & other nonpharmacological measures is inadequate. Adjunct to diet to reduce total-C, LDL-C, TG & Apo B levels in adolescent boys 10-17 yr & girls at least 1 yr post-menarche 10-17 yr w/ heterozygous familial hypercholesterolemia.

Dosage/Direction for Use
Initially 20-40 mg daily in the evening. Dose range: 5-80 mg daily in the evening. High risk of CHD or existing CHD Initially 40 mg daily in the evening. Hyperlipidemia Initially 20 mg daily in the evening. Patient requiring large reduction in LDL-C 40 mg single daily dose in the evening. Mild to moderate hypercholesterolemia Initially 10 mg daily. HoFH 40 mg daily in the evening. Patient on lomitamide, amlodipine Not to exceeed 40 mg daily. Patient on fibrates other than gemfibrozil or fenofibrate Not to exceed 10 mg daily. Patient on amiodarone, verapamil, diltiazem or products containing elbasvir or grazoprevir Not to exceed 20 mg daily. Heterozygous familial hypercholesterolemia in paed patient 10-17 yr Initially 10 mg daily in the evening. Recommended dose range: 10-40 mg daily. Max: 40 mg daily.