Aciclovir

Herpes simplex & varicella zoster infection. Prophylaxis of herpes simplex infection in immunocompromised patients. Tab/susp: Suppression of recurrent herpes simplex infection in immunocompromised patients. Inj: Herpes simplex in neonates.

Tab/susp Adult Herpes simplex 200 mg 5 times daily at 4-hrly intervals (omit nighttime dose) for 5 days, may be doubled to 400 mg in severely immunocompromised patient or those w/ impaired gut absorption. Suppression of herpes simplex in immunocompetent patient 200 mg qds at approx 6-hrly intervals or 400 mg bd at approx 12-hrly intervals, may titrate dose to 200 mg bd or tds. Prophylaxis of herpes simplex infection in immunocompromised patient 200 mg qds at approx 6-hrly interval.Treatment & prophylaxis of herpes simplex infections in immunocompromised childn >2 yr Adult dose, <2 yr ½ adult dose. Renal impairment CrCl <10 mL/min 200 mg bd at approx 12-hrly intervals. Varicella & herpes zoster 800 mg 5 times daily at approx 4-hrly interval for 7 days. Childn ≥6 yr 800 mg qds for 5 days, 2 to <6 yr 400 mg qds for 5 days, <2 yr 200 mg qds for 5 days. Severe renal impairment CrCl <10 mL/min800 mg bd at approx 12-hrly intervals.Moderate renal impairment CrCl 10-25 mL/min800 mg tds at approx 8-hrly intervals. Inj Herpes simplex & varicella zoster Adult 5 mg/kg IV infusion every 8 hr. Infant & childn ≥3 mth 250 mg/m² IV infusion every 8 hr. Herpes encephalitis, immunocompromised patient w/ varicella zoster infection Adult 10 mg/kg IV infusion every 8 hr. Infant & childn 500 mg/m² IV infusion every 8 hr. Prophylaxis of herpes simplex in immunocompromised patient Adult dose. Known suspected neonatal herpes 20 mg/kg IV every 8 hr for 21 days (for disseminated & CNS disease) or 14 days (for disease limited to skin & mucous membranes).