Adult: Dosage is individualised based on treatment goals, patient response and clinical practice guidelines. Initially, 5 or 10 mg once daily; may increase after 4 weeks if necessary. Usual Max: 20 mg once daily; a Max of 40 mg once daily may be used only in patients with severe hypercholesterolaemia at high CV risk who do not achieve the target cholesterol concentration at lower doses and who do not have risk factors for adverse effects. Patients with homozygous familial hypercholesterolaemia may be started on 20 mg once daily. Dosage may be increased at intervals of 2-4 weeks.
Child: Heterozygous familial hypercholesterolaemia: Initially, 5 mg once daily. Usual dose range: 6-9 years 5-10 mg once daily; 10-17 years 5-20 mg once daily. Familial homozygous hypercholesterolaemia: 6-17 years Initially, 5 or 10 mg once daily, depending on age, weight and prior statin use, may titrate dose up to Max of 20 mg once daily according to individual response and tolerability, and depending on treatment recommendations.
Elderly: >70 years Initially, 5 mg once daily.