Description
Contents
Metocloramide
Indications and Dosage
Intravenous
Prophylaxis of chemotherapy-induced nausea and vomiting
Prophylaxis of chemotherapy-induced nausea and vomiting
Adult: Loading dose: 2-4 mg/kg via continuous infusion over 15-20 minutes. Maintenance: 3-5 mg/kg infused over 8-12 hours. Alternatively, initial dose of up to 2 mg/kg via intermittent infusion over at least 15 minutes, may be given before cancer therapy and repeated at 2-hourly intervals. Max total: 10 mg/kg in 24 hours.
Child: As 2nd line option: Usual dose: 1-18 years 0.1-0.15 mg/kg up to tid. 1-<3 years 10-14 kg: 1 mg; 3-<5 years 15-19 kg: 2 mg; 5-<9 years 20-29 kg: 2.5 mg; 9-18 years 30 kg-60 kg: 5 mg; 15-18 years >60 kg: Same as adult dose. All doses to be given up to tid. Max: 0.5 mg/kg in 24 hours. Max duration: 5 days.
Elderly: Dosage reduction may be needed.
Child: As 2nd line option: Usual dose: 1-18 years 0.1-0.15 mg/kg up to tid. 1-<3 years 10-14 kg: 1 mg; 3-<5 years 15-19 kg: 2 mg; 5-<9 years 20-29 kg: 2.5 mg; 9-18 years 30 kg-60 kg: 5 mg; 15-18 years >60 kg: Same as adult dose. All doses to be given up to tid. Max: 0.5 mg/kg in 24 hours. Max duration: 5 days.
Elderly: Dosage reduction may be needed.
Intravenous
Nausea and vomiting, Prophylaxis of nausea and vomiting associated with radiation therapy
Adult: 10 mg up to tid. Max: 30 mg or 0.5mg/kg daily.
Child: As 2nd line option: Usual dose: 1-18 years 0.1-0.15 mg/kg up to tid. 1-<3 years 10-14 kg: 1 mg; 3-<5 years 15-19 kg: 2 mg; 5-<9 years 20-29 kg: 2.5 mg; 9-18 years 30 kg-60 kg: 5 mg; 15-18 years >60 kg: Same as adult dose. All doses to be given up to tid. Max: 0.5 mg/kg in 24 hours. Max duration: 5 days.
Elderly: Dosage reduction may be needed.
Child: As 2nd line option: Usual dose: 1-18 years 0.1-0.15 mg/kg up to tid. 1-<3 years 10-14 kg: 1 mg; 3-<5 years 15-19 kg: 2 mg; 5-<9 years 20-29 kg: 2.5 mg; 9-18 years 30 kg-60 kg: 5 mg; 15-18 years >60 kg: Same as adult dose. All doses to be given up to tid. Max: 0.5 mg/kg in 24 hours. Max duration: 5 days.
Elderly: Dosage reduction may be needed.
Intravenous
Prophylaxis of postoperative nausea and vomiting
Adult: 10 mg as a single dose.
Child: As 2nd line option: Usual dose: 1-18 years 0.1-0.15 mg/kg up to tid. 1-<3 years 10-14 kg: 1 mg; 3-<5 years 15-19 kg: 2 mg; 5-<9 years 20-29 kg: 2.5 mg; 9-18 years 30 kg-60 kg: 5 mg; 15-18 years >60 kg: Same as adult dose. Dose to be given after termination of surgery. Max treatment duration: 48 hours.
Elderly: Dosage reduction may be needed.
Child: As 2nd line option: Usual dose: 1-18 years 0.1-0.15 mg/kg up to tid. 1-<3 years 10-14 kg: 1 mg; 3-<5 years 15-19 kg: 2 mg; 5-<9 years 20-29 kg: 2.5 mg; 9-18 years 30 kg-60 kg: 5 mg; 15-18 years >60 kg: Same as adult dose. Dose to be given after termination of surgery. Max treatment duration: 48 hours.
Elderly: Dosage reduction may be needed.
Intravenous
Intubation of the small intestine, Premedication for radiologic examination of the upper gastrointestinal tract
Adult: 10 mg as a single dose, given over 1-2 minutes.
Child: <6 years 0.1 mg/kg; 6-14 years 2.5-5 mg; >14 years Same as adult dose. All doses to be given as single dose.
Child: <6 years 0.1 mg/kg; 6-14 years 2.5-5 mg; >14 years Same as adult dose. All doses to be given as single dose.
Parenteral
Diabetic gastric stasis
Adult: Severe cases: 10 mg up to 4 times daily via IM or slow IV inj over 1-2 minutes up to 10 days and may shift to oral therapy once possible.
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