Adult: In the management of acute ST-elevation MI: In combination with aspirin (with or without thrombolytics): ≤75 years 300 mg loading dose, followed by 75 mg once daily. Initiate combined treatment as early as possible after symptoms start and continue for at least 4 weeks. In the management of non-ST-elevation MI or unstable angina, including those undergoing stent placement after percutaneous coronary intervention (PCI): In combination with aspirin: 300 mg loading dose, followed by 75 mg once daily.
Elderly: In the management of acute ST-elevation MI: In combination with aspirin (with or without thrombolytics): ≤75 years Same as adult dose; >75 years 75 mg once daily (without a loading dose). Initiate combined treatment as early as possible after symptoms start and continue for at least 4 weeks.

Adult: For patients with recent MI, recent ischaemic stroke, or established peripheral arterial disease: 75 mg once daily. For patients with atrial fibrillation who have at least 1 risk factor for vascular events, are not suitable for vitamin K antagonist treatment, and have low bleeding risk: In combination with aspirin: 75 mg once daily.