Description
Contents
Losartan/Hydrochlorothiazide
Indications/Uses
Hypertension: HYZAAR is indicated for the treatment of hypertension, for patients in whom combination therapy is appropriate.
Hypertensive Patients With Left Ventricular Hypertrophy: HYZAAR is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to BLACK patients.
Dosage/Direction for Use
Hypertension: The usual starting and maintenance dose of HYZAAR is one tablet of HYZAAR 50-12.5 (losartan potassium 50 mg/hydrochlorothiazide 12.5 mg) once daily. For patients who do not respond adequately to HYZAAR 50-12.5, the dosage may be increased to one tablet of FORTZAAR (losartan potassium 100 mg/hydrochlorothiazide 25 mg) once daily or two tablets of HYZAAR 50-12.5 once daily. The maximum dose is one tablet of FORTZAAR once daily or two tablets of HYZAAR 50-12.5 once daily. In general, the antihypertensive effect is attained within three weeks after initiation of therapy. HYZAAR 100-12.5 (losartan potassium 100 mg/hydrochlorothiazide 12.5 mg) is available for those patients titrated to 100 mg of COZAAR who require additional blood pressure control.
Hypertensive Patients With Left Ventricular Hypertrophy: The usual starting dose is 50 mg of losartan once daily. If goal blood pressure is not reached with losartan 50 mg, therapy should be titrated using a combination of losartan and a low dose of hydrochlorothiazide (12.5 mg) and, if needed, the dose should then be increased to losartan 100 mg and hydrochlorothiazide 12.5 mg once daily.
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