Treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhoea) and/or hirsutism in women of reproductive age.
For the treatment of acne, Cyproterone acetate + Ethinylestradiol (Diane-35) should be used when topical therapy or systemic antibiotic treatments has failed.
Since Cyproterone acetate + Ethinylestradiol (Diane-35) is also a hormonal contraceptive, it should not be used in combination with other hormonal contraceptives (see Contraindications).
Tablets must be taken in the order directed on the package every day at about the same time with some liquid as needed. One tablet is to be taken daily for 21 consecutive days. Each subsequent pack is started after a 7-day tablet-free interval, during which time a withdrawal bleed usually occurs. This usually starts on day 2-3 after the last coated tablet and may not have finished before the next pack is started.