Reduction of elevated total cholesterol (total-C), LDL-C, Apo B, total-C: HDL-C ratio & triglycerides & increasing HDL-C in hyperlipidemic & dyslipidemic conditions. Reduction of total mortality & risk of major CV events in adults w/ increased risk of atherosclerotic CV disease based on presence of CV disease risk markers. Primary dysbetalipoproteinemia (type III hyperlipoproteinemia); primary hypercholesterolaemia (type IIa including heterozygous familial hypercholesterolaemia & severe non-familial hypercholesterolaemia); combined (mixed) dyslipidaemia (type IIb); HoFH. Adjunctive therapy to diet to slow progression of atherosclerosis in adults as part of treatment strategy to lower total-C & LDL-C to target levels. Adjunct to diet to reduce total-C, LDL-C & Apo B levels in adolescents at least 1 yr post-menarche, 10-17 yr w/ heterozygous familial hypercholesterolaemia (HeFH).
Usual initial dose: 10 mg once daily. Patient requiring less aggressive LDL-C reductions Initially 5 mg once daily. Dose adjustments can be made after 4-wk interval. Max response is usually achieved w/in 2-4 wk & maintained during chronic therapy. Severe hypercholesterolemia at high CV risk Increase dose to 40 mg. Ped patient 10-17 yr HeFH 5-20 mg daily. Dose adjustments should be made at ≥4-wk interval. Max dose: 20 mg daily. Asian patient Initially 5 mg once daily. Predisposing factors to myopathy Recommended starting dose: 5 mg. Severe renal impairment Initially 5 mg once daily. Not to exceed 10 mg once daily.
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