Description
Contents
Losartan/HCTZ
Indications/Uses
Hypertension:Β FORTZAAR is indicated for the treatment of hypertension, for patients in whom combination therapy is appropriate.
Hypertensive Patients With Left Ventricular Hypertrophy:Β FORTZAAR is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to BLACK patients.
Dosage/Direction for Use
Hypertension:Β The usual starting and maintenance dose of FORTZAAR is one tablet of HYZAAR 50-12.5 (losartan potassium 50 mg/hydrochlorothiazide 12.5 mg) once daily. For patients who do not respond adequately to HYZAAR 50-12.5, the dosage may be increased to one tablet of FORTZAAR (losartan potassium 100 mg/hydrochlorothiazide 25 mg) once daily or two tablets of HYZAAR 50-12.5 once daily. The maximum dose is one tablet of FORTZAAR once daily or two tablets of HYZAAR 50-12.5 once daily. In general, the antihypertensive effect is attained within three weeks after initiation of therapy. HYZAAR 100-12.5 (losartan potassium 100 mg/hydrochlorothiazide 12.5 mg) is available for those patients titrated to 100 mg of COZAAR who require additional blood pressure control.
FORTZAAR should not be initiated in patients who are intravascularly volume-depleted (e.g., those treated with high-dose diuretics).
FORTZAAR is not recommended for patients with severe renal impairment (creatinine clearance β€30 mL/min) or for patients with hepatic impairment.
No initial dosage adjustment of HYZAAR is necessary for elderly patients. FORTZAAR should not be used as initial therapy in elderly patients.
FORTZAAR should not be initiated in patients who are intravascularly volume-depleted (e.g., those treated with high-dose diuretics).
FORTZAAR is not recommended for patients with severe renal impairment (creatinine clearance β€30 mL/min) or for patients with hepatic impairment.
No initial dosage adjustment of HYZAAR is necessary for elderly patients. FORTZAAR should not be used as initial therapy in elderly patients.
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