Adult: 20 mg daily for 5 years.

Adult: Usual dose: 20 mg daily, given as a single dose or in 2 divided doses. Doses of up to 40 mg daily may be given in advanced or metastatic cases; however, no additional clinical benefit has been demonstrated.

Adult: In women with regular menstruation, but with anovular cycles: Initially, 20 mg daily given on days 2-5 of the menstrual cycle. If initial treatment course is unsuccessful, doses may be increased during subsequent menstrual periods to 40 mg then to 80 mg daily. In women with irregular menstruation: Initial course may begin on any day; if there is no response, a subsequent treatment course may start 45 days later with the dose increased to 40 mg then to 80 mg daily. If patient responds with menstruation, then the next course is started on the 2nd day of the cycle.